Granulocyte colony stimulating factor are used to improve the receptivity of the inner lining of the uterus and help in successful implantation. Its more commonly used in patients with chronic thin lining, recurrent implantation failure.

GCSF is usually inserted intra uterine or given sub cutaneously before the embryo transfer and has proven role in treating implantation failures due to thin endometrium (endometrial thickness< 7 mm on ultrasound). Normally we give one or two intrauterine applications of G CSF. if the endometrium still is refractory, we may apply intrauterine platelet rich plasma or PRP. In this 30 ml of blood is withdrawn from patients. This blood is processed using a FDA approved device. From this about 3-4 ml of PRP is extracted. 0.5 ml of prp is instilled into the uterine cavity. Our unit in lilavati hospital Mumbai, was one of the first units in India to achieve pregnancy with intrauterine G CSF many years back. Since then all our IVF units have achieved pregnancies in hundreds of patients with thin endometrium using G CSF, or PRP or a combination of the two.

Step-by-Step Procedure of GCSF

The GCSF injection can be given under the skin or can be instilled inside the endometrial cavity using a atraumatic cannula
The intrauterine gcsf is instilled around the time of embryo transfer
The subcutaneous injection can be given shortly after the embryo transfer

Common Questions

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Yes, gcsf is safe in pregnancy and there is no problem to the baby if gcsf is instilled during the time of embryo transfers
The common side effects include Musculo-skeletal pain
It increases the blood flow to the endometrium and also causes regenerative changes at the level of the endometrium to improve the adherence of the embryo to the lining