Preimplantation Genetic Testing

Preimplantation Genetic Testing

The blastocyst can be genetically analysed using the technique of PGT A (preimplantation genetictesting for aneuploidy). In this the embryo is biopsied. The 3-4 cells of biopsy are sent for genetic analysis. We have our own in-house genetic testing using the S5 Ian Torrent Next Generation Sequencing. The blastocysts are frozen after biopsy on single individual straws, which are numbered. The report of NGS comes in 1 -2 months. After two months we can transfer a single euploid (genetically normal) blastocyst and obtain very high pregnancy rate, with singleton pregnancy and low miscarriage rate. PGT is helpful in couples with multiple implantation failures in selecting genetically normal embryos and thereby decreasing the time taken to pregnancy PGT-A formerly called PGS ( Preimplantation genetic screening) is also offered to women > 35 years of age who desire for single embryo transfer as the risk of abnormal baby increase with age . It can also be offered to patients who have history of recurrent first trimester miscarriages.

Patients who require pre-implantation genetic diagnosis for genetic disorders like thalassemia, sickle cell anaemia, balanced translocation, spinal muscular dystrophy and fragile x syndrome will also need to undergo trophectoderm biopsy, freezing of Blastocyst, testing the cells using NGS and transferring normal embryo in subsequent embryo Transfer cycles. we already have helped few patients of thalassemia and sickle cell anaemia to have normal babies following PGT M

Common Questions

If you could not find an answer to your query, please contact us.

It is a procedure used to identify abnormal genetic composition in embryos created with ivf. This process is typically advised when either of the partners have or are carrying a faulty gene that can cause the baby to have a particular disorder
Though the cost may vary, it usually costs 50 – 60 thousand for doing PGT at our centre.
The result may take around 14-17 working days for the results to come back
Yes, we do recommend a detailed counselling by an expert who will take a detailed history for both the partners and explain the pros and cons and also the risk involved and the limitation of the test.